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Plenvu and Oral Antibiotic Bowel Preparation for Patients before Surgery

For your operation it is necessary for the bowel to be empty. This enables the surgeon to perform a cleaner operation with less risk of infection. Please follow the instructions for the Plenvu bowel cleansing, oral antibiotics and six pre-op drinks that you have been given carefully. A separate information sheet is provided for those with diabetes.

One week before your operation

Unless advised otherwise continue to take prescribed medication as usual. If you take iron tablets stop taking them one week before the examination/operation.

Two days before your operation

You can eat and drink normally up until bedtime. However, we recommend that you avoid heavy meals and alcohol.

The day before your operation

The day before your surgery you should have light, low fibre foods only as described below. You must avoid heavy meals and alcohol. You should drink four of the supplied high carbohydrate drinks during the day. You will have been given Plenvu bowel preparation. The first sachet should be taken at 6pm and the second at 9pm. Both should be mixed with 500ml of water and stirred. These will make you want to go to the toilet, usually within three hours of the first dose. This can be often and urgent. We recommend a day at home within easy reach of the toilet. Try and stay hydrated with clear fluids during the day.

Menu for the day before your operation

Please follow these instructions very carefully. Only the following food is allowed the day before your operation:

Breakfast (8am – 9am) after the first sachet of powder
One boiled egg, not more than one slice of white bread or toast, with butter (no jam or marmalade), one cup of tea or coffee (milk and sugar allowed).

Lunch (12noon – 1.30pm)
A small portion of grilled or poached (not fried) white fish or chicken with a little cooked rice, followed by plain yoghurt or clear jelly. You may also have an egg or small portion of cheese. No potatoes, vegetables or fruit are allowed. A tea or coffee without milk, but sweetened if preferred. Drink plenty of diluted fluids during the afternoon. No further food must be taken after this point.

Day of your operation

On the day of your operation, you should drink the remaining two pre-op carbohydrate drinks. Timing is very important. You must finish these at least 2 hours before your operation.

Morning operation – coming into hospital for 7am – please finish the drinks by 6am.

Afternoon operation – coming into hospital for 11am – please finish the drinks by 11am.

The drinks do not need to be stored in the fridge, but you may prefer them chilled. If you take tablets for your heart, blood pressure or breathing, unless you have been informed otherwise you should take these as normal with a sip of water.

For patients having bowel surgery in the morning

The day before surgeryAction
MorningLight, low residue breakfast
LunchLight, low residue lunch
3pmNo food from this point
Clear fluids only
6pmPlenvu dose 1. Mixed in 500ml of water
Five (5) metronidazole 200mg tablets (=1g metronidazole)
Two (2) neomycin 500mg tablets (=1g neomycin)
9pmPlenvu dose 2. Mixed in 500ml water
Five (5) metronidazole 200mg tablets (=1g metronidazole)
Two (2) neomycin 500mg tablets (=1g neomycin
Morning of surgery
6am2 pre-op drinks then nil by mouth from this point

For patients having bowel surgery in the afternoon

The day before surgeryAction
MorningLight, low residue breakfast
LunchLight, low residue lunch
3pmStop all food intake
Clear fluids only from this point
6pmPlenvu dose 1. Mixed in 500ml of water
Five (5) metronidazole 200mg tablets (=1g metronidazole)
Two (2) neomycin 500mg tablets (=1g neomycin)
Morning of surgery
6amPlenvu dose 2. Mixed in 500ml of water
Five (5) metronidazole 200mg tablets (=1g metronidazole)
Two (2) neomycin 500mg tablets (=1g neomycin
9am2 pre-op drinks then drink water only
11amNil by mouth

Contact numbers

We hope you have found the above information useful. If you have any questions, or are worried about anything, please speak to the pre-assessment nurse specialist on 01305 254222.

About this leaflet

Author: Nathan Curtis, Consultant Surgeon
Written: November 2023
Updated and approved: June 2024
Review date: June 2027
Edition: v1.1

If you have feedback regarding the accuracy of the information contained in this leaflet, or if you would like a list of references used to develop this leaflet, please email patientinformation.leaflets@dchft.nhs.uk

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