Methotrexate Monitoring Information

This leaflet provides additional information about the monitoring required while you are taking methotrexate. It should be read alongside the British Association of Dermatologists (BAD) patient information leaflet.

What is Methotrexate?

Methotrexate is a medicine used to treat a range of inflammatory and immune-related conditions. It is very effective but requires regular monitoring to ensure it remains safe for you.

Why is monitoring needed?

Methotrexate can affect:

• Blood cells
• Liver function
• Kidney function.

Regular blood tests help ensure treatment remains safe and allow early detection of any changes.

How often are tests done?

• Before starting treatment: You will have baseline blood tests, so we know your starting levels.
• During the first few months: Blood tests are usually needed every one to two weeks while your dose is being established. Bloods will be taken at weeks two, four, and six.
• Once stable: Tests become less frequent, typically every two to three months.

If any results come back outside the expected range, we will contact you to discuss what needs to happen next. This may include repeating a test, adjusting your dose, or occasionally pausing the medication.

Please ensure you keep up to date with your blood tests and arrange timely appointments with your GP or at South Walks House.

The South Walks House clinic is located next to Dorchester Library. Phlebotomy clinics operate Monday to Friday, from 8am to 4.30pm. To book an appointment at any of the clinics, please call 01305 254822 between 11am and 2pm. An answerphone service is available after 2pm.

Important safety information

• Methotrexate is usually taken once weekly. Do not take it daily
• Continue taking folic acid as prescribed
• Keep up to date with your blood tests and arrange appointments promptly
• Alcohol should be kept within recommended limits, as this medicine can affect your liver
• Always inform your doctor if you are prescribed new medications.

When should I seek medical advice?

Contact your doctor if you develop:

• Unexplained bruising or bleeding
• Fever or signs of infection
• Shortness of breath
• Persistent nausea or vomiting
• Yellowing of the skin or eyes.

Contact numbers

We hope that you have found this information useful. If you have any questions or are worried about anything, please speak to the following staff:

Dermatology Department 01305 255118 (answer machine, monitored daily) dermatologypractitioners@dchft.nhs.uk

About this leaflet

Authors: Harriet Matthews Nursing Associate, Dr. Ghadah Al-Sharbatee, Specialty Doctor
Written:  February 2026
Approved: May 2026
Review date: May 2029
Edition: v1

If you have feedback regarding the accuracy of the information contained in this leaflet, or if you would like a list of references used to develop this leaflet, please email patientinformation.leaflets@dchft.nhs.uk